Church Lab Web PageWe use quantitative whole genome and proteome measures to guide computational modeling of regulatory and enzymatic networks in microbial and mammalian cells. We develop technologies based on bioinformatics, microarrays, mass-spectrometry, automation, multiplexing, microfluidics, and homologous-recombination genome engineering. We have recently used these to discover new regulatory motifs involved in cell-cycle control, stress response, and many other network components.
Pilpel, Y, Sudarsanam, P and Church, GM (2001) Identifying regulatory networks by combinatorial analysis of promoter elements . Nature Genetics 29(2):153-9. (Supplementary info).
Chen, T, Jaffe, JD. and Church, GM (2001) Algorithms for Identifying Protein Cross-links via Tandem Mass Spectrometry . Recomb 2001. J Comput Biol. 8(6):571-583.